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Nathalie Pamir

Nathalie Pamir

Cardiovascular researcher, Oregon Health & Science University

Appears in 1 story

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DNA hairpin therapy targets the gene behind high cholesterol

New Capabilities

Co-author and collaborator on the PCSK9 study

For two decades, lowering LDL cholesterol meant statins—daily pills that work for most but leave roughly one in five patients with muscle pain or liver enzyme changes severe enough to quit. On May 1, researchers at the University of Barcelona and Oregon Health & Science University published results on a short, engineered DNA molecule that silences the gene controlling how the liver clears LDL, cutting cholesterol by nearly 50 percent in mice after a single injection.

Updated May 7