UK Biobank

Stories

Stored blood samples reveal leukaemia's decades-long evolution

Used to test AML risk of somatic sweeps

In 47 women who later developed acute myeloid leukaemia (AML), blood samples collected annually for up to a decade before diagnosis show the disease's roots often stretch back more than 50 years. Two-thirds had acquired their first driver mutation before age 20.

Updated 2 hours ago

Structural variant map of 467,152 UK Biobank genomes ties rare DNA rearrangements to disease

New Capabilities

Data source for the study; 500,000 UK adults with genomes, health records, and blood protein measurements

AstraZeneca's genomics team scanned 467,152 UK Biobank genomes for structural variants, the large DNA rearrangements most studies skip, and tied them to disease and blood proteins. It is the largest phenome-wide map of structural variants published so far.

Updated Oct 17