Broad Institute of MIT and Harvard

New Capabilities

Collaborator on rare disease applications of the Atlas

Google DeepMind released AlphaGenome Atlas on Tuesday, a free online database that predicts the effects of all 9 billion possible single-letter changes to human DNA. The 1-petabyte resource, built on the AlphaGenome AI model, is the most complete catalogue of human genetic variation ever built.

Updated 3 days ago

New Capabilities

Received 2026 AACR Team Science Award for DepMap; poster presented at AACR 2026; awaiting DepMap portal data release for resistance models

Every year, hundreds of thousands of lung cancer patients start treatment with osimertinib, the leading targeted therapy for tumors driven by mutations in the EGFR gene. Most will respond, but nearly all will eventually stop responding as their cancers evolve resistance through a dozen different molecular escape routes. Until now, researchers had to work with messy lab models that made it hard to pin down which genetic change caused which failure.

Updated May 31

New Capabilities

Home institution of the DefensePredictor team

Every major tool in genetic engineering — from the enzymes that cut DNA in the 1970s to CRISPR gene editing — started as a defense weapon bacteria use against viruses. Two teams revealed bacteria carry three times more weapons than anyone realized, identifying millions of antiviral proteins from tens of thousands of genomes using machine-learning models that flag a new defense system in five minutes.

Updated May 31