Academic Medical Institution
Appears in 2 stories
Produced the landmark metformin-brain pathway study
More than 150 million people take metformin every year to manage Type 2 diabetes. Doctors have prescribed it since 1957, and for most of that time, the consensus was that it works primarily in the liver and gut. A team at Baylor College of Medicine has now shown that at clinically relevant low doses, metformin actually lowers blood sugar by deactivating a protein called Rap1 in a specific cluster of brain neurons — the ventromedial hypothalamus — that acts as a metabolic control center.
Updated Mar 25
Institution where breakthrough was achieved
For nearly six decades, human norovirus has defied laboratory cultivation—making it impossible to develop effective vaccines against a pathogen that sickens 700 million people annually. Researchers at Baylor College of Medicine have now broken that barrier. By blocking chemokine signaling with a drug called TAK-779, the team achieved 10 to 15 consecutive rounds of viral replication in lab-grown human intestinal tissue, enabling production of stable virus stocks for the first time.
Updated Feb 5
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