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Yong Xu

Yong Xu

Co-author, Professor at Baylor College of Medicine

Appears in 1 story

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Scientists discover metformin controls blood sugar through the brain, not just the liver

New Capabilities

Active researcher in hypothalamic neuroscience

More than 150 million people take metformin every year to manage Type 2 diabetes. Doctors prescribed it starting in 1957, and for most of that time, assumed it worked primarily in the liver and gut. A Baylor team found that at clinically relevant low doses, the drug deactivates Rap1 in the ventromedial hypothalamus—a brain region controlling metabolism.

Updated May 30