Uri Alon

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Study of 300 million lab tests finds menopause triggers abrupt body-wide changes

Leading the research team; preparing a randomized trial of pre-menopause hormone therapy

Menopause has long been treated as a slow shutdown of reproduction. An analysis of 300 million lab tests from women in the United States and Israel found a sharper pattern: 52 of 90 markers jump at the final menstrual period, across bone, liver, kidney, lipid and blood systems. Men showed no such step.

Updated 7 days ago

Notable Quotes

Nowadays people check bone density around age 60, but this study would advocate checking around age 40 or 45 and then considering menopausal hormone therapy as prevention.

from Study of 300 million lab tests finds menopause triggers abrupt body-wide changes · Updated 7 days ago

FSH and estradiol are not good enough to detect the exact moment of menopause because of the large fluctuations of perimenopause. It's still an unresolved problem.

from Study of 300 million lab tests finds menopause triggers abrupt body-wide changes · Updated 7 days ago

Nothing can replace a randomized clinical trial.

from Study of 300 million lab tests finds menopause triggers abrupt body-wide changes · Updated 7 days ago

Our data on this are observational and based on a small minority of women who take it, so they should be taken with a grain of salt. We are planning a clinical trial of hormone therapy before the final menstrual period to test its effect on bone and brain health.

from Study of 300 million lab tests finds menopause triggers abrupt body-wide changes · Updated 7 days ago