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Makoto Fukuda

Makoto Fukuda

Lead researcher, Associate Professor at Baylor College of Medicine

Appears in 1 story

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Scientists discover metformin controls blood sugar through the brain, not just the liver

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Active researcher continuing work on brain-metabolism connections

More than 150 million people take metformin every year to manage Type 2 diabetes. Doctors prescribed it starting in 1957, and for most of that time, assumed it worked primarily in the liver and gut. A Baylor team found that at clinically relevant low doses, the drug deactivates Rap1 in the ventromedial hypothalamus—a brain region controlling metabolism.

Updated May 30