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Kiran Bhaskar

Kiran Bhaskar

Professor, Department of Molecular Genetics & Microbiology, UNM School of Medicine

Appears in 1 story

Notable Quotes

"We set out to test whether stabilizing a specific type of ubiquitin chain would help clear toxic tau from neurons. Instead, we discovered something completely unexpected—that OTULIN acts as a master switch controlling whether tau is even produced in the first place." — Dr. Kiran Bhaskar

Stories

OTULIN discovery reveals master switch for tau production

New Capabilities

Co-Director, New Mexico Alzheimer's Disease Research Center

For three decades, Alzheimer's drug development has chased the wrong protein. Billions of dollars and hundreds of failed trials later, researchers at the University of New Mexico have identified OTULIN—an enzyme previously known only for regulating inflammation—as a master switch that controls whether tau protein is produced in the first place. When they disabled OTULIN in neurons, tau vanished entirely, and the cells remained healthy.

Updated Jan 18