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Karthikeyan Tangavelou

Karthikeyan Tangavelou

Senior Scientist, Bhaskar Lab, UNM School of Medicine

Appears in 1 story

Notable Quotes

"Pathological tau is the main player for both brain aging and neurodegenerative disease. If you stop tau synthesis by targeting OTULIN in neurons, you can restore a healthy brain and prevent brain aging." — Dr. Karthikeyan Tangavelou

"Neurons can survive without tau. They are looking healthy, even with the tau removed." — Dr. Karthikeyan Tangavelou

Stories

OTULIN discovery reveals master switch for tau production

New Capabilities

Lead author on OTULIN study

For three decades, billions of dollars, and hundreds of failed trials later, researchers pursued the wrong target. The University of New Mexico team found that OTULIN—an enzyme regulating inflammation—controls tau production, and disabling it in neurons eliminated tau while keeping cells healthy.

Updated May 22