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Jonathan S. Stamler, MD

Jonathan S. Stamler, MD

Lead Researcher and President of Harrington Discovery Institute

Appears in 1 story

Notable Quotes

"We have a new class of drug that prevents weight gain and lowers cholesterol—a potential therapy for obesity and cardiovascular disease, with additional hepatic benefits." — December 2025

"In the liver, nitric oxide inhibits the proteins that make fat and cholesterol. In fat tissue, nitric oxide inhibits the genetic program that makes the enzymes that create fat." — on the mechanism

Stories

Cleveland scientists uncover hidden fat switch

New Capabilities

Leading clinical development of SCoR2 inhibitor

Scientists at University Hospitals Cleveland Medical Center and Case Western Reserve University have identified an enzyme the body needs to make fat—and when they blocked it, mice stopped gaining weight and their cholesterol dropped. The enzyme, called SCoR2, works by stripping nitric oxide from proteins that normally keep fat production in check. Remove SCoR2, and that natural brake stays engaged.

Updated Feb 6