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Carl June

Carl June

Professor of Immunotherapy, University of Pennsylvania

Appears in 1 story

Stories

The gene therapy revolution: from fatal setback to living cures

New Capabilities

Pioneer of CAR-T cell therapy

Gene therapy killed Jesse Gelsinger in 1999. His death triggered FDA shutdowns, lawsuits, and nearly ended the field. Fast forward to December 2025: British scientists published results showing that base-edited immune cells—a 'living drug'—achieved deep remissions in 82% of children with previously incurable T-cell leukemia. Three years after treatment, 64% remain disease-free. Some patients are off treatment entirely.

Updated Jan 9