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New England Journal of Medicine

New England Journal of Medicine

Peer-reviewed medical journal

Appears in 4 stories · Last updated Nov 5, 2026

Stories

Gene therapy infused into the brain cuts seizures in three epilepsy patients

New Capabilities

Published the peer-reviewed trial report

Three adults with epilepsy that drugs could not control agreed to have viruses infused into a small patch of their brains. Their monthly seizures fell by a mean of 92.6%, according to results published in the New England Journal of Medicine.

Updated 6 days ago

Retatrutide phase 3 trial shows 30% average weight loss at 104 weeks

New Capabilities

Publisher of the TRIUMPH-1 results

Eli Lilly's obesity drug retatrutide met its goals in two late-stage trials published in late September. The 12 mg dose produced 30.3% average weight loss over 104 weeks in adults with obesity, per Lilly's topline (the NEJM paper's primary 80-week endpoint was 25.0%), a level once seen mainly after bariatric surgery. In 1,152 adults with type 2 diabetes, the same dose cut weight 18.8% at 80 weeks, and 79% reached an HbA1c of 6.5% or lower.

Updated Oct 18

Septic shock trial finds fewer fluids and earlier vasopressors no better than standard care

New Capabilities

Publisher of ARISE FLUIDS and the earlier trials in this arc

Septic shock treatment rests on a simple rule: give fluids fast and plenty of them. A trial in the New England Journal of Medicine tested the opposite strategy — less fluid, earlier vasopressors — and found patients did just as well.

Updated Oct 17

New tick-borne virus behind unexplained fevers found in China

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As of September 2026: Published the ALTNV study

Nearly one in ten patients with tick-bite fevers in a new Chinese study carried a virus that had never been seen before. Researchers named it Asian longhorned tick nairovirus (ALTNV), after the tick species that spreads it, and reported the finding in the New England Journal of Medicine.

Updated Sep 30